Product Description: gamma-tubulin complex component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0000923 | equatorial microtubule organizing center |
| Component | GO:0000930 | gamma-tubulin complex |
| Component | GO:0008275 | gamma-tubulin small complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0043015 | gamma-tubulin binding |
| Process | GO:0031122 | cytoplasmic microtubule organization |
| Process | GO:0051321 | meiotic cell cycle |
| Process | GO:0051415 | microtubule nucleation by interphase microtubule organizing center |
| Process | GO:0000278 | mitotic cell cycle |
| Process | GO:0051225 | spindle assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.14 | 0.93 |
| Trophozoite | possibly expressed | 0.88 | 0.54 |
| Schizont | not expressed | 0.52 | 0.71 |
| Gametocyte | possibly expressed | 1.42 | 0.32 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0933500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.169 | MFS: -2.768 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2I3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101925
Most Similar Human Ortholog: Q96CW5
TM-align score: 0.65 | RMSD: 4.11
Seq Identity: 0.22 | Length: 654 / 1512
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126216 | tubulin gamma complex associated protein 3 |
| ENSG00000282003 | tubulin gamma complex associated protein 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 74 | 24 | 103 |
| disruptive | 34 | 138 | 68 | 182 |
| missense | 20 | 116 | 61 | 161 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 134 | 64 | 109 |
| disruptive | 74 | 245 | 145 | 302 |
| missense | 42 | 205 | 124 | 236 |
PlasmoDB Total SNPs: 112
Non-coding: 23 | Synonymous: 59 | Nonsynonymous: 30 | Stop Codon: 0
Protein Length: 1512 | Molecular Weight (kDa): 180.493
UniProt ID(s): Q8I2I3
PDB ID(s): None
Isoelectric Point: 8.28
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007259 | Gamma-tubulin complex component protein |
| InterPro | IPR040457 | Gamma tubulin complex component, C-terminal |
| InterPro | IPR041470 | Gamma tubulin complex component protein, N-terminal |
| PFam | PF04130 | Gamma tubulin complex component, C-terminal |
| PFam | PF17681 | Gamma tubulin complex component protein, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |