PF3D7_0933700

Genome location: Pf3D7_09_v3:1,334,102..1,335,151(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.30	0.81
Schizont	expressed	0.21	0.86
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0933700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.159 | MFS: -2.805 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H589

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533123

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	10	5	9
disruptive	1	9	5	21
missense	1	9	5	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	20	4	14
disruptive	4	21	20	35
missense	2	18	15	28

PlasmoDB Total SNPs: 71

Non-coding: 66 | Synonymous: 2 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 184 | Molecular Weight (kDa): 22.163

UniProt ID(s): C0H589

PDB ID(s): None

Isoelectric Point: 10.02

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A