Product Description: Fip1 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.88 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0933900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.663 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2H9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103053
Most Similar Human Ortholog: Q6UN15
TM-align score: 0.26 | RMSD: 5.81
Seq Identity: 0.17 | Length: 110 / 250
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145216 | factor interacting with PAPOLA and CPSF1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 9 | 14 |
| disruptive | 9 | 40 | 25 | 66 |
| missense | 3 | 29 | 19 | 47 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 11 | 14 |
| disruptive | 19 | 106 | 37 | 109 |
| missense | 9 | 74 | 24 | 60 |
PlasmoDB Total SNPs: 140
Non-coding: 112 | Synonymous: 22 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 250 | Molecular Weight (kDa): 29.456
UniProt ID(s): Q8I2H9
PDB ID(s): None
Isoelectric Point: 4.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007854 | Pre-mRNA polyadenylation factor Fip1 domain |
| PFam | PF05182 | Pre-mRNA polyadenylation factor Fip1 domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |