PF3D7_0934600

Genome location: Pf3D7_09_v3:1,354,207..1,355,815(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.16	0.92
Trophozoite	expressed	0.02	0.99
Schizont	expressed	0.25	0.88
Gametocyte	possibly expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0934600

Resistome Missense Mutations: K130I

Resistome Compounds with Missense Mutations: KAE678/NITD678

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.214 | MFS: -3.297 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2H2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533488

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	10	5	12
disruptive	6	20	15	22
missense	6	20	15	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	20	10	12
disruptive	11	44	14	38
missense	11	39	13	18

PlasmoDB Total SNPs: 113

Non-coding: 104 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 188 | Molecular Weight (kDa): 22.69

UniProt ID(s): Q8I2H2

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035987	Ribosomal protein S8 superfamily
PFam	N/A	N/A
Superfamily	SSF56047	Ribosomal protein S8 superfamily