PF3D7_0934700

Genome location: Pf3D7_09_v3:1,357,159..1,360,704(+)

Genome classification: Core

Function and Localization

Product Description: UBX domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.33	0.84
Trophozoite	expressed	0.97	0.50
Schizont	expressed	1.01	0.47
Gametocyte	expressed	1.44	0.33

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0934700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.318 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0835500)

Relative Growth Rate: 0.91 ± 0.26
Confidence: 4.08

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0835500)

Modification: Disrupted | RMgm-2464

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2H1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102329

Most Similar Human Ortholog: D6RBG6

TM-align score: 0.55 | RMSD: 1.08

Seq Identity: 0.23 | Length: 30 / 531

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000113194	Fas associated factor family member 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	20	14	39
disruptive	22	28	23	67
missense	15	23	21	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	57	21	29
disruptive	34	88	54	121
missense	21	62	41	76

PlasmoDB Total SNPs: 257

Non-coding: 216 | Synonymous: 27 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 531 | Molecular Weight (kDa): 62.57

UniProt ID(s): Q8I2H1

PDB ID(s): None

Isoelectric Point: 7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001012	UBX domain
InterPro	IPR006577	UAS
InterPro	IPR029071	Ubiquitin-like domain superfamily
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF00789	UBX domain
PFam	PF14555
Superfamily	SSF52833	Thioredoxin-like superfamily
Superfamily	SSF54236	Ubiquitin-like domain superfamily

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104