PF3D7_0934900

Genome location: Pf3D7_09_v3:1,364,066..1,366,174(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.05	0.97
Schizont	possibly expressed	0.05	0.97
Gametocyte	expressed	0.13	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0934900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.987 | MFS: -2.438 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0835700)

Modification: Disrupted | RMgm-2466

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2H0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532924

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	21	13	36
disruptive	5	45	41	90
missense	4	44	40	81

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	45	25	38
disruptive	23	101	62	118
missense	16	87	60	97

PlasmoDB Total SNPs: 76

Non-coding: 43 | Synonymous: 30 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 539 | Molecular Weight (kDa): 65.551

UniProt ID(s): Q8I2H0

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A