Genome location: Pf3D7_09_v3:1,367,396..1,367,930(-)
Genome classification: Core
Product Description: protein kish, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0046907 | intracellular transport |
| Process | GO:0009306 | protein secretion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.65 | 0.69 |
| Trophozoite | no data | 0.96 | 0.49 |
| Schizont | no data | 0.33 | 0.80 |
| Gametocyte | no data | 0.35 | 0.80 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0935100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.528 | MFS: -2.386 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H590
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102262
Most Similar Human Ortholog: Q8TBQ9
TM-align score: 0.72 | RMSD: 2.26
Seq Identity: 0.47 | Length: 72 / 72
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000174695 | transmembrane protein 167A |
| ENSG00000215717 | transmembrane protein 167B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 17
Non-coding: 14 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 72 | Molecular Weight (kDa): 8.004
UniProt ID(s): C0H590
PDB ID(s): None
Isoelectric Point: 8.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009653 | Protein kish |
| PFam | PF06842 | Protein kish |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31726165 | Structure, rheological, thermal and antioxidant properties of cell wallpolysaccharides from Chinese quince fruits | Qin Z, Liu HM, Lv TT, Wang XD | 10.1016/j.ijbiomac.2019.10.083 |