Genome location: Pf3D7_09_v3:1,368,257..1,372,877(-)
Genome classification: Core
Product Description: vacuolar protein sorting-associated protein 33, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005886 | plasma membrane |
Component | GO:0030141 | secretory granule |
Function | GO:0019905 | syntaxin binding |
Process | GO:0006886 | intracellular protein transport |
Process | GO:0006904 | vesicle docking involved in exocytosis |
Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.67 | 0.69 |
Trophozoite | expressed | 1.11 | 0.45 |
Schizont | expressed | 0.57 | 0.70 |
Gametocyte | possibly expressed | 1.13 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0935200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -3.101 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0836000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2G8
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=6.60) with 3LQQ (Global RMSD=12.81)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101460
Most Similar Human Ortholog: Q96AX1
TM-align score: 0.89 | RMSD: 2.92
Seq Identity: 0.27 | Length: 575 / 1147
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000139719 | VPS33A core subunit of CORVET and HOPS complexes |
ENSG00000256861 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 48 | 28 | 55 |
disruptive | 92 | 234 | 91 | 203 |
missense | 44 | 120 | 58 | 116 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 24 | 84 | 37 | 63 |
disruptive | 159 | 370 | 135 | 267 |
missense | 74 | 206 | 88 | 158 |
PlasmoDB Total SNPs: 219
Non-coding: 78 | Synonymous: 77 | Nonsynonymous: 64 | Stop Codon: 0
Protein Length: 1147 | Molecular Weight (kDa): 135.978
UniProt ID(s): Q8I2G8
PDB ID(s): None
Isoelectric Point: 4.56
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001619 | Sec1-like protein |
InterPro | IPR027121 | Vacuolar protein sorting-associated protein 33 |
InterPro | IPR036045 | Sec1-like superfamily |
PFam | PF00995 | Sec1-like protein |
Superfamily | SSF56815 | Sec1-like superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |