PF3D7_0935300

Genome location: Pf3D7_09_v3:1,372,874..1,374,250(+)

Genome classification: Core

Function and Localization

Product Description: phosphatidylinositol N-acetylglucosaminyltransferase subunit P, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: 2.4.1.198 (Phosphatidylinositol N-acetylglucosaminyltransferase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.02	0.99
Schizont	expressed	0.01	1.00
Gametocyte	expressed	0.02	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0935300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.134 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0836100)

Relative Growth Rate: 0.05 ± 0.09
Confidence: 6.29

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2G7

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.4.1.198	phosphatidylinositol N-acetylglucosaminyltransferase	iodoacetic acidN-ethylmaleimideSH-alkylating reagentsp-chloromercuriphenylsulfonic acid

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102977

Most Similar Human Ortholog: P57054

TM-align score: 0.76 | RMSD: 2.67

Seq Identity: 0.22 | Length: 112 / 121

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000185808	phosphatidylinositol glycan anchor biosynthesis class P

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	1	0	0
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 116

Non-coding: 108 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 121 | Molecular Weight (kDa): 14.48

UniProt ID(s): Q8I2G7

PDB ID(s): None

Isoelectric Point: 4.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013717	PIG-P
InterPro	IPR016542	Phosphatidylinositol N-acetylglucosaminyltransferase, GPI19/PIG-P subunit
PFam	PF08510	PIG-P
Superfamily	N/A	N/A