Genome location: Pf3D7_09_v3:1,377,653..1,381,134(+)
Genome classification: Core
Product Description: gametocyte development protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.38 | 0.77 |
| Schizont | expressed | 0.17 | 0.90 |
| Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0935400
Resistome Missense Mutations: G277C
Resistome Compounds with Missense Mutations: AN10248, AN13762
Resistome # Samples with Disruptive Mutations: 6 (5 missense, 5 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.26 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2G6
"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.63) with 3N3M (Global RMSD=19.56)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 22 | 16 | 44 |
| disruptive | 15 | 37 | 32 | 61 |
| missense | 15 | 37 | 29 | 57 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 56 | 36 | 49 |
| disruptive | 22 | 101 | 60 | 124 |
| missense | 21 | 91 | 55 | 86 |
PlasmoDB Total SNPs: 166
Non-coding: 124 | Synonymous: 23 | Nonsynonymous: 18 | Stop Codon: 1
Protein Length: 599 | Molecular Weight (kDa): 71.964
UniProt ID(s): A0A6G8HJJ3, A0A6G8HJK0, A0A6G8HJK1, A0A6G8HJL0, A0A6G8HJN3, A0A6G8HJP1, A0A6G8HJP3, Q25986, Q8I2G6
PDB ID(s): None
Isoelectric Point: 8.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23093935 | Plasmodium falciparum gametocyte development 1 (Pfgdv1) and gametocytogenesisearly gene identification and commitment to sexual development. | Eksi S, Morahan BJ, ..., Williamson KC | 10.1371/journal.ppat.1002964 |
| 29590075 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependentgene silencing. | Filarsky M, Fraschka SA, ..., Voss TS | 10.1126/science.aan6042 |
| 31086187 | Plasmodium falciparum sexual differentiation in malaria patients is associatedwith host factors and GDV1-dependent genes. | Usui M, Prajapati SK, ..., Williamson KC | 10.1038/s41467-019-10172-6 |
| 34011691 | A 39-Amino-Acid C-Terminal Truncation of GDV1 Disrupts Sexual Commitment inPlasmodium falciparum | Tiburcio M, Hitz E, ..., Treeck M | 10.1128/mSphere.01093-20 |
| 34376675 | CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool forPlasmodium falciparum malaria transmission research | Boltryk SD, Passecker A, ..., Voss TS | 10.1038/s41467-021-24954-4 |
| 33053503 | Metabolic regulation of sexual commitment in Plasmodium falciparum | Neveu G, Beri D, Kafsack BF | 10.1016/j.mib.2020.09.004 |
| 29752147 | Sex in Plasmodium falciparum: Silence Play between GDV1 and HP1 | Rea E, Le Roch KG, Tewari R | 10.1016/j.pt.2018.04.006 |
| 24644299 | Genome-wide analysis of selection on the malaria parasite Plasmodium falciparumin West African populations of differing infection endemicity | Mobegi VA, Duffy CW, ..., Conway DJ | 10.1093/molbev/msu106 |
| 30361631 | Multi-population genomic analysis of malaria parasites indicates local selectionand differentiation at the gdv1 locus regulating sexual development | Duffy CW, Amambua-Ngwa A, ..., Conway DJ | 10.1038/s41598-018-34078-3 |
| 35950755 | Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in DiversePlasmodium falciparum Clinical Isolates and Transcriptome Scans for CorrelatingGenes | Hocking SE, Stewart LB, ..., Conway DJ | 10.1128/mbio.01948-22 |
| 36515553 | Patterns of Heterochromatin Transitions Linked to Changes in the Expression ofPlasmodium falciparum Clonally Variant Genes | Michel-Todo L, Bancells C, ..., Cortes A | 10.1128/spectrum.03049-22 |
| 36409095 | Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolatesand Diverse Laboratory-Adapted Lines | Stewart LB, Freville A, ..., Conway DJ | 10.1128/spectrum.02234-22 |
| 31227704 | Publisher Correction: Plasmodium falciparum sexual differentiation in malariapatients is associated with host factors and GDV1-dependent genes | Usui M, Prajapati SK, ..., Williamson KC | 10.1038/s41467-019-10805-w |