About Gene List

PF3D7_0935600 (GIG)

Genome location: Pf3D7_09_v3:1,403,986..1,407,459(+)

Genome classification: Core

Function and Localization

Product Description: gametocytogenesis-implicated protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.74 0.66
Trophozoite expressed 0.10 0.95
Schizont expressed 0.12 0.93
Gametocyte possibly expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0935600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.682 | MFS: -2.371 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2G4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532937

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 27 6 22
disruptive 38 47 19 50
missense 30 31 16 44

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 45 13 23
disruptive 49 77 35 87
missense 37 54 28 61

PlasmoDB Total SNPs: 214

Non-coding: 126 | Synonymous: 50 | Nonsynonymous: 36 | Stop Codon: 2

Protein Information

Protein Length: 512 | Molecular Weight (kDa): 58.344

UniProt ID(s): Q8I2G4, Q8WQK6

PDB ID(s): None

Isoelectric Point: 3.75

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g