PF3D7_0935900 (REX1)

Genome location: Pf3D7_09_v3:1,419,960..1,424,840(-)

Genome classification: Core

Function and Localization

Product Description: ring-exported protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Component	GO:0005737	cytoplasm
Component	GO:1903561	extracellular vesicle
Component	GO:0030430	host cell cytoplasm
Component	GO:0033644	host cell membrane
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	3.30	0.13
Trophozoite	expressed	0.87	0.63
Schizont	expressed	0.75	0.64
Gametocyte	not expressed	0.42	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0935900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.989 | MFS: -1.863 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2G1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532805

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	14	13	19
disruptive	16	19	11	36
missense	16	15	10	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	30	17	20
disruptive	22	46	21	73
missense	19	34	17	59

PlasmoDB Total SNPs: 296

Non-coding: 181 | Synonymous: 88 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 713 | Molecular Weight (kDa): 83.041

UniProt ID(s): Q8I2G1, Q8MPL1

PDB ID(s): None

Isoelectric Point: 5.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
15481109	A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer'sclefts.	Hawthorne PL, Trenholme KR, ..., Gardiner DL	10.1016/j.molbiopara.2004.03.013
19172295	Initial characterization of Pf62, a novel protein of Plasmodium falciparumidentified by immunoscreening.	Moyano EM, Gonzalez LM, ..., Benito A	10.1007/s00436-009-1335-y
21696460	Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodiumfalciparum virulence complex.	Dixon MW, Kenny S, ..., Tilley L	10.1111/j.1365-2958.2011.07740.x
25062022	Characterization of the small exported Plasmodium falciparum membrane proteinSEMP1.	Dietz O, Rusch S, ..., Beck HP	10.1371/journal.pone.0103272
26304012	A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparumcontrols export machinery architecture and virulence protein trafficking.	McHugh E, Batinovic S, ..., Tilley L	10.1111/mmi.13201
28944300	Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome.	Abdi A, Yu L, ..., Rayner J	10.12688/wellcomeopenres.11910.2
29324251	Potential role of Plasmodium falciparum exported protein 1 in the chloroquinemode of action.	Lisewski AM, Quiros JP, ..., Lichtarge O	10.1016/j.ijpddr.2017.12.003
31476617	A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes.	Takano R, Kozuka-Hata H, ..., Kato K	10.1016/j.isci.2019.07.035
32184257	Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking	McHugh E, Carmo OMS, ..., Dixon MWA	10.1128/mBio.03320-19
33774908	Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells.	Jonsdottir TK, Counihan NA, ..., Gilson PR	10.1111/cmi.13332