PF3D7_0936000 (REX2)

Genome location: Pf3D7_09_v3:1,426,152..1,428,942(-)

Genome classification: Core

Function and Localization

Product Description: ring-exported protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020036	Maurer's cleft
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.47	0.44
Trophozoite	expressed	0.24	0.88
Schizont	expressed	0.13	0.93
Gametocyte	not expressed	0.10	0.95

More info:

Old (Pf3D7v3) Gene ID: PF3D7_0936000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.297 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

AlphaFill Uniprot ID: Q8I2G0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Ortholog Group (OrthoMCL): OG6_533369

No human ortholog(s)

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 154

Non-coding: 140 | Synonymous: 1 | Nonsynonymous: 9 | Stop Codon: 4

Protein Length: 94 | Molecular Weight (kDa): 10.771

UniProt ID(s): Q8I2G0, Q9NFH5

PDB ID(s): None

Isoelectric Point: 7.74

Protein Domain Annotations:

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16760427	A cluster of ring stage-specific genes linked to a locus implicated incytoadherence in Plasmodium falciparum codes for PEXEL-negative andPEXEL-positive proteins exported into the host cell.	Spielmann T, Hawthorne PL, ..., Gardiner DL	10.1091/mbc.e06-04-0291
31476617	A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes.	Takano R, Kozuka-Hata H, ..., Kato K	10.1016/j.isci.2019.07.035
36888656	Diverse yeast antiviral systems prevent lethal pathogenesis caused by the L-Amycovirus	Chau S, Gao J, ..., Meneghini MD	10.1073/pnas.2208695120