About Gene List

PF3D7_0936300 (REX3)

Genome location: Pf3D7_09_v3:1,435,767..1,439,273(-)

Genome classification: Core

Function and Localization

Product Description: ring-exported protein 3

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.94 0.31
Trophozoite expressed 0.32 0.85
Schizont expressed 0.21 0.88
Gametocyte expressed 0.23 0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0936300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.924 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2F7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215347

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 250

Non-coding: 174 | Synonymous: 21 | Nonsynonymous: 54 | Stop Codon: 1

Protein Information

Protein Length: 326 | Molecular Weight (kDa): 37.589

UniProt ID(s): Q8I2F7

PDB ID(s): None

Isoelectric Point: 4.21

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16760427 A cluster of ring stage-specific genes linked to a locus implicated incytoadherence in Plasmodium falciparum codes for PEXEL-negative andPEXEL-positive proteins exported into the host cell. Spielmann T, Hawthorne PL, ..., Gardiner DL 10.1091/mbc.e06-04-0291
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596