About Gene List

PF3D7_0936400 (REX4)

Genome location: Pf3D7_09_v3:1,439,258..1,442,180(+)

Genome classification: Core

Function and Localization

Product Description: ring-exported protein 4

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0030430 host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.37 0.83
Trophozoite expressed 0.12 0.94
Schizont expressed 0.05 0.97
Gametocyte expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0936400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.142 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2F6

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.23) with 8H6U (Global RMSD=13.01)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215347

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 11 2 8
disruptive 10 20 12 33
missense 10 20 11 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 17 2 13
disruptive 13 53 25 65
missense 13 44 16 33

PlasmoDB Total SNPs: 153

Non-coding: 140 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 26.347

UniProt ID(s): Q8I2F6

PDB ID(s): None

Isoelectric Point: 6.05

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16760427 A cluster of ring stage-specific genes linked to a locus implicated incytoadherence in Plasmodium falciparum codes for PEXEL-negative andPEXEL-positive proteins exported into the host cell. Spielmann T, Hawthorne PL, ..., Gardiner DL 10.1091/mbc.e06-04-0291
19755146 Synthetic peptides from conserved regions of the Plasmodium falciparum earlytranscribed membrane and ring exported proteins bind specifically to red bloodcell proteins Garcia J, Curtidor H, ..., Patarroyo ME 10.1016/j.vaccine.2009.09.009
30198089 CRISPR/Cpf1 facilitated large fragment deletion in Saccharomyces cerevisiae Li ZH, Liu M, ..., Wei DZ 10.1002/jobm.201800195
15525710 The RNA catabolic enzymes Rex4p, Rnt1p, and Dbr1p show genetic interaction withtrans-acting factors involved in processing of ITS1 in Saccharomyces cerevisiaepre-rRNA Faber AW, Vos JC, ..., Raue HA 10.1261/rna.7155904
12364601 Deletions in the S1 domain of Rrp5p cause processing at a novel site in ITS1 ofyeast pre-rRNA that depends on Rex4p Eppens NA, Faber AW, ..., Raue HA 10.1093/nar/gkf538