Genome location: Pf3D7_09_v3:1,443,260..1,445,400(-)
Genome classification: Core
Product Description: virulence-associated protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0033644 | host cell membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0050839 | cell adhesion molecule binding |
| Process | GO:0009405 | obsolete pathogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.03 | 0.99 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.32 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0936500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.933 | MFS: -2.829 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2F5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 12 | 4 | 12 |
| disruptive | 15 | 48 | 22 | 57 |
| missense | 8 | 40 | 20 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 20 | 4 | 16 |
| disruptive | 26 | 97 | 32 | 79 |
| missense | 15 | 79 | 22 | 63 |
PlasmoDB Total SNPs: 79
Non-coding: 58 | Synonymous: 10 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 259 | Molecular Weight (kDa): 31.178
UniProt ID(s): Q8I2F5
PDB ID(s): None
Isoelectric Point: 9.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25703704 | Discovery of a novel and conserved Plasmodium falciparum exported protein that isimportant for adhesion of PfEMP1 at the surface of infected erythrocytes. | Nacer A, Claes A, ..., Mattei D | 10.1111/cmi.12430 |