Genome location: Pf3D7_09_v3:1,445,945..1,448,525(+)
Genome classification: Core
Product Description: gametocyte exported protein 5
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0044164 | host cell cytosol |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.05 | 0.97 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.40 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0936600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.178 | MFS: -3.293 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2F4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 14 | 17 | 17 |
| disruptive | 7 | 21 | 5 | 26 |
| missense | 7 | 21 | 5 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 29 | 14 | 18 |
| disruptive | 13 | 47 | 29 | 57 |
| missense | 12 | 40 | 26 | 41 |
PlasmoDB Total SNPs: 139
Non-coding: 126 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 297 | Molecular Weight (kDa): 34.909
UniProt ID(s): Q8I2F4
PDB ID(s): None
Isoelectric Point: 6.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25106850 | A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. | Tarr SJ, Moon RW, Hardege I, Osborne AR | 10.1016/j.molbiopara.2014.07.011 |
| 26315106 | Specific expression and export of the Plasmodium falciparum Gametocyte EXportedProtein-5 marks the gametocyte ring stage. | Tiburcio M, Dixon MW, ..., Alano P | 10.1186/s12936-015-0853-6 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 31086187 | Plasmodium falciparum sexual differentiation in malaria patients is associatedwith host factors and GDV1-dependent genes | Usui M, Prajapati SK, ..., Williamson KC | 10.1038/s41467-019-10172-6 |
| 33903595 | Higher gametocyte production and mosquito infectivity in chronic compared toincident Plasmodium falciparum infections | Barry A, Bradley J, ..., Bousema T | 10.1038/s41467-021-22573-7 |