Product Description: Plasmodium exported protein (PHISTc), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0033644 | host cell membrane |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.37 | 0.50 |
| Trophozoite | expressed | 0.54 | 0.77 |
| Schizont | not expressed | 0.26 | 0.86 |
| Gametocyte | not expressed | 0.13 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0936800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.996 | MFS: -1.879 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I2F2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 12 | 3 | 13 |
| disruptive | 5 | 44 | 20 | 45 |
| missense | 3 | 39 | 19 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 9 | 23 |
| disruptive | 11 | 87 | 39 | 123 |
| missense | 9 | 68 | 25 | 76 |
PlasmoDB Total SNPs: 180
Non-coding: 121 | Synonymous: 35 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 383 | Molecular Weight (kDa): 45.5
UniProt ID(s): Q8I2F2
PDB ID(s): 4JLE
Isoelectric Point: 10.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22249178 | Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1(PfEMP1) intracellular domain reveals a conserved interaction epitope. | Mayer C, Slater L, ..., Vakonakis I | 10.1074/jbc.M111.330779 |
| 24983468 | A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 andcomigrates to knobs on the host cell surface. | Oberli A, Slater LM, ..., Vakonakis I | 10.1096/fj.14-256057 |
| 29154995 | A map of the subcellular distribution of phosphoinositides in the erythrocyticcycle of the malaria parasite Plasmodium falciparum. | Ebrahimzadeh Z, Mukherjee A, Richard D | 10.1016/j.ijpara.2017.08.015 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 33774908 | Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. | Jonsdottir TK, Counihan NA, ..., Gilson PR | 10.1111/cmi.13332 |