PF3D7_0937000

Genome location: Pf3D7_09_v3:1,465,306..1,467,827(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043657	host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.02	0.99
Trophozoite	no data	0.02	0.99
Schizont	no data	0.01	1.00
Gametocyte	no data	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0937000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.938 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H593

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532843

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	13	9	16
disruptive	19	47	31	71
missense	13	45	26	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	27	11	19
disruptive	25	114	46	105
missense	19	92	38	68

PlasmoDB Total SNPs: 101

Non-coding: 70 | Synonymous: 18 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 357 | Molecular Weight (kDa): 42.968

UniProt ID(s): C0H593

PDB ID(s): None

Isoelectric Point: 8.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019111	Plasmodium RESA, N-terminal
PFam	PF09687	Plasmodium RESA, N-terminal
Superfamily	N/A	N/A