About Gene List

PF3D7_0937100

Genome location: Pf3D7_09_v3:1,468,280..1,469,641(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.00 1.00
Trophozoite no data 0.01 0.99
Schizont no data 0.00 1.00
Gametocyte no data 0.09 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0937100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.127 | MFS: -3.178 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2E9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533258

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 12 4 15
disruptive 32 40 23 50
missense 29 38 19 42

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 19 10 18
disruptive 45 85 39 62
missense 37 66 34 36

PlasmoDB Total SNPs: 48

Non-coding: 12 | Synonymous: 5 | Nonsynonymous: 30 | Stop Codon: 1

Protein Information

Protein Length: 258 | Molecular Weight (kDa): 31.287

UniProt ID(s): Q8I2E9

PDB ID(s): None

Isoelectric Point: 10.24

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12