PF3D7_0937200

Genome location: Pf3D7_09_v3:1,471,599..1,473,298(+)

Genome classification: Core

Function and Localization

Product Description: lysophospholipase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.1.5 (Lysophospholipase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane
Function	GO:0016298	lipase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	expressed	0.02	0.99
Schizont	possibly expressed	0.00	1.00
Gametocyte	not expressed	0.12	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0937200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.698 | MFS: -3.164 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1220300)

Relative Growth Rate: 1.09 ± 0.18
Confidence: 4.84

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2E8

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.1.5	lysophospholipase	NEMSDSEDTAPCMBEGTAPMSFDMSOCaCl2FeCl3xyleneethanolsulfite...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100231

Most Similar Human Ortholog: A0A3B3ITT3

TM-align score: 0.85 | RMSD: 1.92

Seq Identity: 0.18 | Length: 242 / 357

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000074416	monoglyceride lipase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	15	10	12
disruptive	17	43	23	71
missense	15	39	19	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	24	10	16
disruptive	27	84	42	100
missense	23	74	32	66

PlasmoDB Total SNPs: 91

Non-coding: 60 | Synonymous: 10 | Nonsynonymous: 18 | Stop Codon: 3

Protein Information

Protein Length: 357 | Molecular Weight (kDa): 40.803

UniProt ID(s): Q8I2E8

PDB ID(s): None

Isoelectric Point: 6.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006494	Plasmodium subtelomeric PST-A
InterPro	IPR022742	Serine aminopeptidase, S33
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF12146	Serine aminopeptidase, S33
Superfamily	SSF53474	Alpha/Beta hydrolase fold