PF3D7_0937600 (VAR)

Genome location: Pf3D7_09_v3:1,486,070..1,490,187(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0937600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.645 | MFS: -2.427 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I2E4

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=0.26) with 5MZA (Global RMSD=4.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 936

Non-coding: 35 | Synonymous: 397 | Nonsynonymous: 498 | Stop Codon: 6

Protein Information

Protein Length: 1315 | Molecular Weight (kDa): 151.986

UniProt ID(s): A0A5P1A0B7, A0A5P1A185, A0A5P1A1A9, Q8I2E4

PDB ID(s): None

Isoelectric Point: 5.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008602	Duffy-antigen binding
InterPro	IPR029210	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
InterPro	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF05424	Duffy-antigen binding
PFam	PF15445	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF15447	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
Superfamily	SSF140924	N/A