About Gene List

PF3D7_1000300 (RIF)

Genome location: Pf3D7_10_v3:41,773..42,963(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: rifin

SignalP Peptide: MKLHCSKILLFLLPLNILVTSLS

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020002 host cell plasma membrane
Process GO:0020033 antigenic variation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte possibly expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1000300

Resistome Missense Mutations: G86S, D109N, L311I, L312I, V315A

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -1.958 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK35

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100719

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 655

Non-coding: 77 | Synonymous: 134 | Nonsynonymous: 442 | Stop Codon: 2

Protein Information

Protein Length: 345 | Molecular Weight (kDa): 38.13

UniProt ID(s): Q8IK35

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006373 Variant surface antigen Rifin
PFam PF02009 Variant surface antigen Rifin
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10430943 Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. Kyes SA, Rowe JA, Kriek N, Newbold CI 10.1073/pnas.96.16.9333
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094