Product Description: chondroitin sulfate A ligand
SignalP Peptide: MLFSFKYIYFSSTFLLLLVLQSKT
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0044228 | host cell surface |
| Component | GO:0020030 | infected host cell surface knob |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.17 | 0.92 |
| Trophozoite | possibly expressed | 0.47 | 0.77 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | not expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1001000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.359 | MFS: -2.235 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK27
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 67
Non-coding: 49 | Synonymous: 10 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 231 | Molecular Weight (kDa): 27.617
UniProt ID(s): Q8IK27
PDB ID(s): None
Isoelectric Point: 9.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15671043 | Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. | Vincensini L, Richert S, ..., Braun Breton C | 10.1074/mcp.M400176-MCP200 |
| 34718641 | An Invariant Protein That Colocalizes With VAR2CSA on Plasmodiumfalciparum-Infected Red Cells Binds to Chondroitin Sulfate A. | Keitany GJ, Jenkins BJ, ..., Duffy PE | 10.1093/infdis/jiab550 |
| 14977967 | Antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes tochondroitin sulfate A and to the C terminus of merozoite surface protein 1correlate with reduced placental malaria in Cameroonian women | Taylor DW, Zhou A, ..., Leke RF | 10.1128/IAI.72.3.1603-1607.2004 |