About Gene List

PF3D7_1001100 (ACBP1)

Genome location: Pf3D7_10_v3:66,845..69,602(-)

Genome classification: Core

Function and Localization

Product Description: acyl-CoA binding protein, isoform 1, ACBP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Function GO:0000062 fatty-acyl-CoA binding
Process GO:0006631 fatty acid metabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed nd nd
Trophozoite not expressed nd nd
Schizont possibly expressed nd nd
Gametocyte not expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1001100.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.355 | MFS: -2.246 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZ93

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 174

Non-coding: 61 | Synonymous: 36 | Nonsynonymous: 73 | Stop Codon: 4

Protein Information

Protein Length: 313 | Molecular Weight (kDa): 36.504

UniProt ID(s): Q8IK25

PDB ID(s): None

Isoelectric Point: 7.36

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
InterPro IPR035984 Acyl-CoA binding protein superfamily
PFam PF00887 Acyl-CoA-binding protein, ACBP
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily SSF47027 Acyl-CoA binding protein superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30362657 Synergistic roles of acyl-CoA binding protein (ACBP1) and sterol carrier protein2 (SCP2) in Toxoplasma lipid metabolism Fu Y, Cui X, ..., Liu Q 10.1111/cmi.12970