PF3D7_1001200 (ACBP2)

Genome location: Pf3D7_10_v3:69,800..71,269(-)

Genome classification: Core

Function and Localization

Product Description: acyl-CoA binding protein, isoform 2, ACBP2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0000062	fatty-acyl-CoA binding
Process	GO:0006631	fatty acid metabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.35	0.86
Trophozoite	expressed	2.19	0.17
Schizont	expressed	0.41	0.79
Gametocyte	not expressed	0.11	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1001200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -1.554 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1427500)

Relative Growth Rate: 0.97 ± 0.08
Confidence: 6.51

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1427500)

Modification: Disrupted | RMgm-3875

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK24

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.25) with 1HBK (Global RMSD=1.02)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103494

Most Similar Human Ortholog: Q5T8D3

TM-align score: 0.90 | RMSD: 1.68

Seq Identity: 0.30 | Length: 90 / 90

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107897	acyl-CoA binding domain containing 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 33

Non-coding: 32 | Synonymous: 0 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 90 | Molecular Weight (kDa): 10.767

UniProt ID(s): Q8IK24

PDB ID(s): None

Isoelectric Point: 7.92

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000582	Acyl-CoA-binding protein, ACBP
InterPro	IPR035984	Acyl-CoA binding protein superfamily
PFam	PF00887	Acyl-CoA-binding protein, ACBP
Superfamily	SSF47027	Acyl-CoA binding protein superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30352931	Comprehensive Characterization of Toxoplasma Acyl Coenzyme A-Binding ProteinTgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism	Fu Y, Cui X, ..., Liu Q	10.1128/mBio.01597-18