About Gene List

PF3D7_1001300

Genome location: Pf3D7_10_v3:72,601..74,029(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTa), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0044164 host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite possibly expressed 0.82 0.57
Schizont possibly expressed 0.11 0.93
Gametocyte not expressed 0.04 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1001300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.345 | MFS: -2.923 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK23

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110760

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 7 2 16
disruptive 10 29 11 33
missense 9 26 10 26

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 12 4 18
disruptive 17 55 24 49
missense 14 44 21 35

PlasmoDB Total SNPs: 53

Non-coding: 36 | Synonymous: 7 | Nonsynonymous: 9 | Stop Codon: 1

Protein Information

Protein Length: 278 | Molecular Weight (kDa): 33.143

UniProt ID(s): Q8IK23

PDB ID(s): None

Isoelectric Point: 4.89

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25106850 A conserved domain targets exported PHISTb family proteins to the periphery ofPlasmodium infected erythrocytes. Tarr SJ, Moon RW, Hardege I, Osborne AR 10.1016/j.molbiopara.2014.07.011