Product Description: exported lipase 1
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 3.1.1.5 (Lysophospholipase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0044164 | host cell cytosol |
| Component | GO:0016020 | membrane |
| Function | GO:0016298 | lipase activity |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.99 | 0.57 |
| Trophozoite | expressed | 0.16 | 0.92 |
| Schizont | not expressed | 0.11 | 0.94 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1001400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.633 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK22
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.1.5 | lysophospholipase | NEMSDSEDTAPCMBEGTAPMSFDMSOCaCl2FeCl3xyleneethanolsulfite... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 14 | 38 |
| disruptive | 34 | 80 | 44 | 109 |
| missense | 34 | 79 | 43 | 97 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 48 | 24 | 51 |
| disruptive | 47 | 182 | 84 | 165 |
| missense | 41 | 162 | 70 | 112 |
PlasmoDB Total SNPs: 125
Non-coding: 61 | Synonymous: 40 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 921 | Molecular Weight (kDa): 107.656
UniProt ID(s): Q19KB0, Q19KB1, Q19KB2, Q8IK22
PDB ID(s): None
Isoelectric Point: 4.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022742 | Serine aminopeptidase, S33 |
| InterPro | IPR029058 | Alpha/Beta hydrolase fold |
| PFam | PF12146 | Serine aminopeptidase, S33 |
| Superfamily | SSF53474 | Alpha/Beta hydrolase fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 27795395 | Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection | Spillman NJ, Dalmia VK, Goldberg DE | 10.1128/mBio.01538-16 |
| 31476617 | A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infectedErythrocytes. | Takano R, Kozuka-Hata H, ..., Kato K | 10.1016/j.isci.2019.07.035 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 37256270 | Investigation of exopolysaccharide formation and its impact on anaerobicsuccinate production with Vibrio natriegens | Schulze C, Hadrich M, ..., Blombach B | 10.1111/1751-7915.14277 |