PF3D7_1001500 (ETRAMP10)

Genome location: Pf3D7_10_v3:80,302..82,576(-)

Genome classification: Core

Function and Localization

Product Description: early transcribed membrane protein 10.1

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020005	symbiont-containing vacuole membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	3.60	0.11
Trophozoite	expressed	1.13	0.55
Schizont	expressed	0.86	0.60
Gametocyte	possibly expressed	0.49	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1001500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0524800)

Relative Growth Rate: 0.97 ± 0.19
Confidence: 4.69

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK21

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_141182

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	1	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 60

Non-coding: 58 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 107 | Molecular Weight (kDa): 11.267

UniProt ID(s): Q8IK21

PDB ID(s): None

Isoelectric Point: 10.61

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006389	Early transcribed membrane protein (ETRAMP)
PFam	PF09716	Early transcribed membrane protein (ETRAMP)
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12686607	etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface.	Spielmann T, Fergusen DJ, Beck HP	10.1091/mbc.e02-04-0240
34715088	Plasmodium early transcribed membrane proteins appear tailored to the host rangeof malaria parasites	Brandsma AM, Hilmer C, ..., Montagna GN	10.1016/j.ijpara.2021.08.005
34252120	Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccineantigens using chimeric rodent parasites	Kolli SK, Salman AM, ..., Janse CJ	10.1371/journal.pone.0254498
31058097	A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes,Sporozoites, and Liver-Stages	Marin-Mogollon C, Salman AM, ..., Khan SM	10.3389/fcimb.2019.00096
20228203	Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorousvacuole and exported protein in blood stages	Mackellar DC, O'Neill MT, ..., Kappe SH	10.3)