PF3D7_1001700

Genome location: Pf3D7_10_v3:92,437..94,615(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: MQPRPCAVFFVAVVFIFLKNA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1001700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.451 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK19

"Best" AlphaFill ligand hit: 3PG (3-phosphoglyceric acid, Local RMSD=1.07) with 2VFE (Global RMSD=18.90)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144691

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 65

Non-coding: 48 | Synonymous: 6 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 266 | Molecular Weight (kDa): 32.184

UniProt ID(s): Q8IK19

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations: