Product Description: Plasmodium exported protein (hyp16), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0044228 | host cell surface |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.52 | 0.75 |
| Trophozoite | not expressed | 0.17 | 0.89 |
| Schizont | possibly expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1001900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.551 | MFS: -3.082 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK17
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 8 | 3 | 11 |
| disruptive | 6 | 15 | 11 | 35 |
| missense | 6 | 14 | 9 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 15 | 3 | 14 |
| disruptive | 10 | 48 | 21 | 79 |
| missense | 9 | 34 | 17 | 50 |
PlasmoDB Total SNPs: 54
Non-coding: 48 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 276 | Molecular Weight (kDa): 32.138
UniProt ID(s): Q8IK17
PDB ID(s): None
Isoelectric Point: 7.11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15671043 | Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. | Vincensini L, Richert S, ..., Braun Breton C | 10.1074/mcp.M400176-MCP200 |
| 29162636 | Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum SurfaceAntigens and Possible Vaccine Candidates. | Nilsson Bark SK, Ahmad R, ..., Marti M | 10.1074/mcp.RA117.000076 |
| 30576479 | Plasmodium falciparum protein ' PfJ23' hosts distinct binding sites for majorvirulence factor ' PfEMP1' and Maurer's cleft marker ' PfSBP1' | Kaur J, Kumar V, ..., Hora R | 10.1093/femspd/fty090 |
| 32184257 | Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking | McHugh E, Carmo OMS, ..., Dixon MWA | 10.1128/mBio.03320-19 |