About Gene List

PF3D7_1002000

Genome location: Pf3D7_10_v3:102,837..105,100(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp2), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 1.08 0.56
Trophozoite not expressed 0.12 0.94
Schizont not expressed 0.11 0.94
Gametocyte not expressed 0.05 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.749 | MFS: -2.735 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK16

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=1.29) with 3A4L (Global RMSD=15.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127462

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 7 6 15
disruptive 14 35 18 36
missense 11 29 16 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 10 17 17
disruptive 26 72 29 83
missense 16 52 25 60

PlasmoDB Total SNPs: 134

Non-coding: 84 | Synonymous: 33 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 469 | Molecular Weight (kDa): 55.271

UniProt ID(s): Q8IK16

PDB ID(s): None

Isoelectric Point: 6.95

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12