About Gene List

PF3D7_1002100 (PTP5)

Genome location: Pf3D7_10_v3:106,648..109,855(-)

Genome classification: Core

Function and Localization

Product Description: EMP1-trafficking protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0044164 host cell cytosol
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 2.79 0.16
Trophozoite expressed 0.80 0.59
Schizont expressed 0.69 0.64
Gametocyte possibly expressed 0.32 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.618 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK15

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125968

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 9 6 5
disruptive 13 28 12 43
missense 11 26 11 36

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 14 8 15
disruptive 21 54 41 92
missense 18 40 34 64

PlasmoDB Total SNPs: 196

Non-coding: 65 | Synonymous: 76 | Nonsynonymous: 54 | Stop Codon: 1

Protein Information

Protein Length: 631 | Molecular Weight (kDa): 69.851

UniProt ID(s): Q25993, Q8IK15

PDB ID(s): None

Isoelectric Point: 5.8

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
29487358 PV1, a novel Plasmodium falciparum merozoite dense granule protein, interactswith exported protein in infected erythrocytes. Morita M, Nagaoka H, ..., Takashima E 10.1038/s41598-018-22026-0
32184257 Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking McHugh E, Carmo OMS, ..., Dixon MWA 10.1128/mBio.03320-19
30995911 Hospital-derived antibody profiles of malaria patients in Southwest India Venkatesh A, Jain A, ..., Rathod PK 10.1186/s12936-019-2771-5