About Gene List

PF3D7_1002200 (PArt)

Genome location: Pf3D7_10_v3:110,388..116,655(+)

Genome classification: Core

Function and Localization

Product Description: tryptophan-rich antigen 3

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.69 0.70
Trophozoite expressed 1.36 0.38
Schizont expressed 0.45 0.74
Gametocyte not expressed 0.26 0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002200

Resistome Missense Mutations: G292S

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.437 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK14

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532877

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 13 5 20
disruptive 17 40 39 99
missense 17 32 33 79

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 19 16 44
disruptive 30 129 80 230
missense 22 93 58 146

PlasmoDB Total SNPs: 220

Non-coding: 159 | Synonymous: 35 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 979 | Molecular Weight (kDa): 118.671

UniProt ID(s): Q5EF37, Q8IK14

PDB ID(s): None

Isoelectric Point: 5.19

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022089 Tryptophan/threonine-rich plasmodium antigen, C-terminal
PFam PF12319 Tryptophan/threonine-rich plasmodium antigen, C-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
15383306 Characterisation of a tryptophan-rich Plasmodium falciparum antigen associatedwith merozoites. Ntumngia FB, Bouyou-Akotet MK, ..., Kun JF 10.1016/j.molbiopara.2004.06.008
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104