PF3D7_1002300

Genome location: Pf3D7_10_v3:117,242..118,534(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.02	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.919 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1200700)

Modification: Disrupted | RMgm-1298

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK13

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533077

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	8	13
disruptive	4	22	11	57
missense	4	22	11	52

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	11	31
disruptive	12	63	41	121
missense	11	49	38	79

PlasmoDB Total SNPs: 11

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 430 | Molecular Weight (kDa): 49.982

UniProt ID(s): Q8IK13

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A