About Gene List

PF3D7_1002600

Genome location: Pf3D7_10_v3:125,343..127,695(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.12 0.93
Trophozoite expressed 0.54 0.68
Schizont not expressed 0.10 0.93
Gametocyte not expressed 0.12 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -1.933 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK10

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533490

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 22 10 33
disruptive 28 81 44 93
missense 20 68 40 81

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 49 22 33
disruptive 56 161 96 159
missense 36 126 75 114

PlasmoDB Total SNPs: 80

Non-coding: 18 | Synonymous: 33 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 553 | Molecular Weight (kDa): 66.475

UniProt ID(s): Q8IK10

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
19435743 ESG: extended similarity group method for automated protein function prediction. Chitale M, Hawkins T, Park C, Kihara D 10.1093/bioinformatics/btp309
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895