PF3D7_1002700

Genome location: Pf3D7_10_v3:128,151..132,481(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.11	0.94
Trophozoite	possibly expressed	0.50	0.71
Schizont	possibly expressed	0.44	0.73
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002700

Resistome Missense Mutations: E47A

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.478 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1201100)

Relative Growth Rate: 0.96 ± 0.20
Confidence: 4.62

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1201100)

Modification: Disrupted | RMgm-3168

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK09

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532373

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	46	19	49
disruptive	20	128	79	136
missense	20	119	76	117

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	92	29	48
disruptive	57	277	120	281
missense	49	231	96	165

PlasmoDB Total SNPs: 190

Non-coding: 96 | Synonymous: 47 | Nonsynonymous: 46 | Stop Codon: 1

Protein Information

Protein Length: 944 | Molecular Weight (kDa): 111.602

UniProt ID(s): Q8IK09

PDB ID(s): None

Isoelectric Point: 5.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A