PF3D7_1002800

Genome location: Pf3D7_10_v3:132,914..138,022(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.52	0.71
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.90	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.177 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK08

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533694

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	87	37	107
disruptive	60	291	134	298
missense	45	265	118	257

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	170	62	111
disruptive	134	610	227	454
missense	95	497	176	291

PlasmoDB Total SNPs: 201

Non-coding: 36 | Synonymous: 96 | Nonsynonymous: 67 | Stop Codon: 2

Protein Information

Protein Length: 1425 | Molecular Weight (kDa): 170.851

UniProt ID(s): Q8IK08

PDB ID(s): None

Isoelectric Point: 9.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
Superfamily	SSF46565	Chaperone J-domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094