PF3D7_1002900

Genome location: Pf3D7_10_v3:138,050..140,161(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.09	0.95
Trophozoite	possibly expressed	0.18	0.88
Schizont	possibly expressed	0.12	0.91
Gametocyte	possibly expressed	0.13	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1002900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.147 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK07

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532363

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	8	4	10
disruptive	4	4	19
missense	4	4	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	15	2	10
disruptive	2	26	12	32
missense	1	21	10	20

PlasmoDB Total SNPs: 136

Non-coding: 122 | Synonymous: 14 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 127 | Molecular Weight (kDa): 14.517

UniProt ID(s): Q8IK07

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A