About Gene List

PF3D7_1003000

Genome location: Pf3D7_10_v3:141,402..147,095(+)

Genome classification: Core

Function and Localization

Product Description: guanylate cyclase organizer UGO, putative

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Component GO:0032991 protein-containing complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite possibly expressed 0.08 0.95
Schizont expressed 1.02 0.48
Gametocyte expressed 0.45 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1003000

Resistome Missense Mutations: I349K

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 3 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.337 | MFS: -2.609 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK06

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533766

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 73 51 79
disruptive 44 164 79 210
missense 28 130 54 159

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 30 149 72 84
disruptive 100 374 159 417
missense 56 268 116 247

PlasmoDB Total SNPs: 266

Non-coding: 123 | Synonymous: 103 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 1272 | Molecular Weight (kDa): 149.593

UniProt ID(s): Q8IK06

PDB ID(s): None

Isoelectric Point: 9.65

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097