About Gene List

PF3D7_1003200

Genome location: Pf3D7_10_v3:149,289..150,204(+)

Genome classification: Core

Function and Localization

Product Description: ribosome-binding factor A, putative

SignalP Peptide: MFLYFLLFLFTLTYINNT

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.08 0.95
Schizont not expressed 0.03 0.98
Gametocyte possibly expressed 0.10 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1003200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -3.365 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1201600)

  • Relative Growth Rate: 0.24 ± 0.10
  • Confidence: 5.97

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1201600)

Modification: Disrupted | RMgm-3170

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK05

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_144999

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 4 19
disruptive 2 6 4 18
missense 2 6 4 17

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 28 6 16
disruptive 2 20 14 51
missense 2 18 13 35

PlasmoDB Total SNPs: 65

Non-coding: 55 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 199 | Molecular Weight (kDa): 24.277

UniProt ID(s): Q8IK05

PDB ID(s): None

Isoelectric Point: 9.71

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000238 Ribosome-binding factor A
InterPro IPR023799 Ribosome-binding factor A domain superfamily
PFam PF02033 Ribosome-binding factor A
Superfamily SSF89919 Ribosome-binding factor A domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895