Product Description: N-terminal acetyltransferase A complex catalytic subunit ARD1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.1.88 (Transferred entry: 2.3.1.254, 2.3.1.255, 2.3.1.256, 2.3.1.257, 2.3.1.258and 2.3.1.259)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031415 | NatA complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0008080 | N-acetyltransferase activity |
| Function | GO:0004596 | peptide alpha-N-acetyltransferase activity |
| Function | GO:1990190 | peptide-glutamate-N-acetyltransferase activity |
| Function | GO:1990189 | peptide-serine-N-acetyltransferase activity |
| Process | GO:0018002 | N-terminal peptidyl-glutamic acid acetylation |
| Process | GO:0017198 | N-terminal peptidyl-serine acetylation |
| Process | GO:0006474 | N-terminal protein amino acid acetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.18 | 0.89 |
| Schizont | expressed | 0.21 | 0.86 |
| Gametocyte | expressed | 0.09 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1003300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.165 | MFS: -3.23 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK04
"Best" AlphaFill ligand hit: CMC (carboxymethyl coenzyme *a, Local RMSD=0.10) with 6ZMP (Global RMSD=3.04)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.88 | peptide alpha-N-acetyltransferase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100590
Most Similar Human Ortholog: P41227
TM-align score: 0.97 | RMSD: 0.84
Seq Identity: 0.48 | Length: 151 / 152
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102030 | N-alpha-acetyltransferase 10, NatA catalytic subunit |
| ENSG00000156269 | N-alpha-acetyltransferase 11, NatA catalytic subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 133
Non-coding: 127 | Synonymous: 4 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 152 | Molecular Weight (kDa): 17.935
UniProt ID(s): Q8IK04
PDB ID(s): None
Isoelectric Point: 8.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000182 | GNAT domain |
| InterPro | IPR016181 | Acyl-CoA N-acyltransferase |
| PFam | PF00583 | GNAT domain |
| Superfamily | SSF55729 | Acyl-CoA N-acyltransferase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |