PF3D7_1003400

Genome location: Pf3D7_10_v3:152,012..158,777(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.94
Trophozoite	not expressed	0.18	0.90
Schizont	expressed	1.38	0.42
Gametocyte	expressed	1.30	0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1003400

Resistome Missense Mutations: I1222M

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.115 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1201800)

Modification: Disrupted | RMgm-3171

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK03

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134616

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	107	51	123
disruptive	83	367	177	387
missense	59	320	159	330

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	201	83	140
disruptive	155	682	287	546
missense	104	569	246	369

PlasmoDB Total SNPs: 329

Non-coding: 72 | Synonymous: 158 | Nonsynonymous: 98 | Stop Codon: 1

Protein Information

Protein Length: 2050 | Molecular Weight (kDa): 243.183

UniProt ID(s): Q8IK03

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094