Product Description: 40S ribosomal protein S20e, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.46 | 0.78 |
| Trophozoite | expressed | 0.62 | 0.65 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1003500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.124 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK02
"Best" AlphaFill ligand hit: PAR (crestomycin, Local RMSD=0.60) with 4DR2 (Global RMSD=1.99)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100367
Most Similar Human Ortholog: G3XAN0
TM-align score: 0.90 | RMSD: 1.01
Seq Identity: 0.69 | Length: 64 / 118
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000008988 | ribosomal protein S20 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 197
Non-coding: 189 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 118 | Molecular Weight (kDa): 13.513
UniProt ID(s): Q8IK02
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001848 | Ribosomal protein S10 |
| InterPro | IPR005729 | Ribosomal protein S10, eukaryotic/archaeal |
| InterPro | IPR027486 | Ribosomal protein S10 domain |
| InterPro | IPR036838 | Ribosomal protein S10 domain superfamily |
| PFam | PF00338 | Ribosomal protein S10 domain |
| Superfamily | SSF54999 | Ribosomal protein S10 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |