About Gene List

PF3D7_1003600 (IMC1c)

Genome location: Pf3D7_10_v3:164,213..166,726(+)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1c

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.39 0.86
Trophozoite possibly expressed 0.03 0.98
Schizont expressed 0.80 0.69
Gametocyte expressed 0.20 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1003600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.46 | MFS: -2.402 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1202000)

  • Relative Growth Rate: 0.68 ± 0.13
  • Confidence: 5.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1202000)

Modification: Mutated | RMgm-4129

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IK01

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146159

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 111

Non-coding: 105 | Synonymous: 2 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 281 | Molecular Weight (kDa): 32.654

UniProt ID(s): Q8IK01

PDB ID(s): None

Isoelectric Point: 7.35

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022086 Inner membrane complex protein
PFam PF12314 Inner membrane complex protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597
26791088 Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues. Vieira WA, Coetzer TL 10.1186/s12936-015-1065-9
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
34324609 Plasmodium falciparum PhIL1-associated complex plays an essential role inmerozoite reorientation and invasion of host erythrocytes. Saini E, Sheokand PK, ..., Malhotra P 10.1371/journal.ppat.1009750
28223095 Palmitoylation of Plasmodium alveolins promotes cytoskeletal function Tremp AZ, Al-Khattaf FS, Dessens JT 10.1016/j.molbiopara.2017.02.003