Product Description: MKT1 domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0017108 | 5'-flap endonuclease activity |
| Function | GO:0048256 | flap endonuclease activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | possibly expressed | 0.11 | 0.93 |
| Schizont | not expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1003700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.427 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IK00
"Best" AlphaFill ligand hit: SRY (streptomycin a, Local RMSD=2.02) with 3HAV (Global RMSD=17.75)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 55 | 38 | 94 |
| disruptive | 52 | 184 | 91 | 184 |
| missense | 31 | 155 | 85 | 156 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 24 | 129 | 57 | 81 |
| disruptive | 90 | 350 | 135 | 264 |
| missense | 51 | 289 | 123 | 186 |
PlasmoDB Total SNPs: 223
Non-coding: 107 | Synonymous: 69 | Nonsynonymous: 46 | Stop Codon: 1
Protein Length: 1308 | Molecular Weight (kDa): 153.349
UniProt ID(s): Q8IK00
PDB ID(s): None
Isoelectric Point: 6.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006084 | XPG/Rad2 endonuclease |
| InterPro | IPR022039 | Temperature dependent protein affecting M2 dsRNA replication, C-terminal |
| InterPro | IPR022040 | Temperature dependent protein affecting M2 dsRNA replication, N-terminal |
| InterPro | IPR029060 | PIN-like domain superfamily |
| InterPro | IPR037314 | MKT1, H3TH domain |
| PFam | PF12246 | Temperature dependent protein affecting M2 dsRNA replication, C-terminal |
| PFam | PF12247 | Temperature dependent protein affecting M2 dsRNA replication, N-terminal |
| Superfamily | SSF88723 | PIN-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |