Product Description: U5 small nuclear ribonucleoprotein component, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0003723 | RNA binding |
| Function | GO:0030623 | U5 snRNA binding |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.51 | 0.76 |
| Trophozoite | expressed | 0.78 | 0.57 |
| Schizont | expressed | 0.13 | 0.92 |
| Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1003800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.047 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1314800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJZ9
"Best" AlphaFill ligand hit: APR (adenosine-5-diphosphoribose, Local RMSD=0.15) with 1ZM2 (Global RMSD=1.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100212
Most Similar Human Ortholog: Q15029
TM-align score: 0.92 | RMSD: 1.85
Seq Identity: 0.49 | Length: 918 / 1235
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108883 | elongation factor Tu GTP binding domain containing 2 |
| ENSG00000167658 | eukaryotic translation elongation factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 64 | 44 | 83 |
| disruptive | 29 | 108 | 76 | 187 |
| missense | 23 | 103 | 69 | 176 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 146 | 60 | 86 |
| disruptive | 47 | 249 | 120 | 252 |
| missense | 40 | 211 | 105 | 197 |
PlasmoDB Total SNPs: 195
Non-coding: 118 | Synonymous: 44 | Nonsynonymous: 33 | Stop Codon: 0
Protein Length: 1235 | Molecular Weight (kDa): 142.944
UniProt ID(s): Q8IJZ9
PDB ID(s): None
Isoelectric Point: 4.67
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000640 | Elongation factor EFG, domain V-like |
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| InterPro | IPR005517 | Translation elongation factor EFG/EF2, domain IV |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR031950 | 116kDa U5 small nuclear ribonucleoprotein component, N-terminal |
| InterPro | IPR035647 | EF-G domain III/V-like |
| InterPro | IPR035655 | 116kDa U5 small nuclear ribonucleoprotein component, C-terminal |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF00679 | Elongation factor EFG, domain V-like |
| PFam | PF03144 | Translation elongation factor EFTu-like, domain 2 |
| PFam | PF03764 | Translation elongation factor EFG/EF2, domain IV |
| PFam | PF16004 | 116kDa U5 small nuclear ribonucleoprotein component, N-terminal |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF54980 | EF-G domain III/V-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |