PF3D7_1003900

Genome location: Pf3D7_10_v3:177,921..178,870(+)

Genome classification: Core

Function and Localization

Product Description: dynein attachment factor-domain containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.97
Schizont	possibly expressed	0.02	0.99
Gametocyte	not expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1003900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.699 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1202300)

Relative Growth Rate: 1.02 ± 0.09
Confidence: 6.29

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1202300)

Modification: Disrupted | RMgm-3173

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJZ8

"Best" AlphaFill ligand hit: TQP (, Local RMSD=0.61) with 5U21 (Global RMSD=21.80)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126570

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	9	13
disruptive	6	40	26	61
missense	6	40	21	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	25	13	14
disruptive	13	99	45	91
missense	10	87	32	48

PlasmoDB Total SNPs: 47

Non-coding: 34 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 254 | Molecular Weight (kDa): 30.941

UniProt ID(s): Q8IJZ8

PDB ID(s): None

Isoelectric Point: 9.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR031733	Dynein attachment factor, N-terminal
PFam	PF15867	Dynein attachment factor, N-terminal
Superfamily	N/A	N/A