Product Description: 60S ribosomal protein L13, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0017148 | negative regulation of translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.62 | 0.34 |
| Trophozoite | expressed | 1.84 | 0.24 |
| Schizont | expressed | 0.46 | 0.73 |
| Gametocyte | expressed | 1.09 | 0.46 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1004000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.136 | MFS: -3.168 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1202400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJZ7
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.55) with 5HKV (Global RMSD=6.33)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100793
Most Similar Human Ortholog: A0A7I2V5L3
TM-align score: 0.97 | RMSD: 1.04
Seq Identity: 0.50 | Length: 187 / 202
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142541 | ribosomal protein L13a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 14 | 5 | 12 |
| disruptive | 0 | 8 | 6 | 12 |
| missense | 0 | 8 | 6 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 12 | 9 |
| disruptive | 4 | 21 | 7 | 33 |
| missense | 2 | 17 | 6 | 29 |
PlasmoDB Total SNPs: 127
Non-coding: 120 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 202 | Molecular Weight (kDa): 23.754
UniProt ID(s): Q8IJZ7
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.79
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005755 | Ribosomal protein L13, eukaryotic/archaeal |
| InterPro | IPR005822 | Ribosomal protein L13 |
| InterPro | IPR036899 | Ribosomal protein L13 superfamily |
| PFam | PF00572 | Ribosomal protein L13 |
| Superfamily | SSF52161 | Ribosomal protein L13 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |