PF3D7_1004100

Genome location: Pf3D7_10_v3:182,244..187,100(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.13	0.94
Trophozoite	not expressed	0.06	0.96
Schizont	not expressed	0.04	0.98
Gametocyte	not expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1004100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.269 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJZ6

"Best" AlphaFill ligand hit: PAM (palmitoleic acid, Local RMSD=6.96) with 3GBG (Global RMSD=15.98)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533697

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	78	54	86
disruptive	27	188	106	277
missense	19	169	98	245

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	170	58	104
disruptive	68	422	160	374
missense	46	362	138	269

PlasmoDB Total SNPs: 293

Non-coding: 168 | Synonymous: 85 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 1190 | Molecular Weight (kDa): 141.922

UniProt ID(s): Q8IJZ6

PDB ID(s): None

Isoelectric Point: 8.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
PFam	N/A	N/A
Superfamily	SSF50998	Quinoprotein alcohol dehydrogenase-like superfamily